The carbon tetrachloride model in mice

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August undefined, 2024

網頁2010年7月9日 · The carbon tetrachloride (CCl4)-induced mouse model has been historically relied upon to study liver injury and regeneration. We exposed mice to CCl4 to … 網頁Phenobarbital was administered once as a CYP inducer in the carbon tetrachloride-induced hepatitis model mice. The mRNA expression levels of Cyp3a11 and Cyp2b10 in the liver and small intestine were measured using reverse transcription polymerase chain …

The carbon tetrachloride model in mice Semantic Scholar

網頁In hepatocytes, carbon tetrachloride (CCl 4) is transformed into trichloromethyl free radicals that can trigger cell damage that can lead to hepatocellular injuries such as fibrosis and cirrhosis (Zhao et al., 2024a ), resulting in oxidative stress, inflammation, and pyroptosis (Otrubova et al., 2024 ). 網頁Carbon tetrachloride, also known as tetrachloromethane, is an organic compound with the chemical formula CCl4. This compound is often classified as a polyhalogenated organic compound since it consists of a carbon atom which is attached to more than one halide functional group. black hills circuit race

Carbon tetrachloride - Wikipedia

網頁2015年4月2日 · In the first section we focus on the carbon tetrachloride (CCl 4) model in mice, which is the toxic model of liver fibrosis induction most commonly used … 網頁Carbon tetrachloride, also known by many other names (such as tetrachloromethane, also recognised by the IUPAC, carbon tet in the cleaning industry, Halon-104 in firefighting, and Refrigerant-10 in HVACR) is a chemical compound with the chemical formula CCl4. It is a colourless liquid with a "sweet" smell that can be detected at low levels. It ... 網頁principle. In the first section we focus on the carbon tetrachloride (CCl 4) model in mice, which is the toxic model of liver fibrosis induction most commonly used worldwide. … gaming chair jysk

Standard operating procedures in experimental liver research: …

Attenuation of phenobarbital‐induced cytochrome P450 expression in carbon tetrachloride‐induced hepatitis in mice models …

網頁2024年6月14日 · In this study, we investigated the protective effects of hSAP against carbon tetrachloride (CCl 4 )-induced acute liver injury in mice, including hepatoprotective and anti-inflammatory effects in acute liver injury, as well as the potential of hSAP to inhibit the migration and activation of HSCs. Materials and methods hSAP 網頁11 小時前 · et al. Dissociation between liver inflammation and hepatocellular damage induced by carbon tetrachloride in myeloid cell-specific ... in a charcot-marie-tooth 2D mouse model . Neuron 51, 715–726 ... gaming chair keeps lowering網頁2024年9月25日 · This study evaluated the severity of liver fibrosis induction by intraperitoneal carbon tetrachloride (CCl 4) injections in mice. 29 male C57BL/6N mice … gaming chair junior size

"網頁Consumption of Goats' Milk Protects Mice From Carbon Tetrachloride-Induced Acute Hepatic Injury and Improves the Associated ... (AST) and expression of the … " - The carbon tetrachloride model in mice

The carbon tetrachloride model in mice

Mouse model of carbon tetrachloride induced liver fibrosis: Histopathological changes and expression of CD133 and epidermal growth factor - PubMed

網頁2024年11月26日 · This is the first study to investigate the hepatoprotective effect of CQ on acute liver injury caused by carbon tetrachloride (CCl 4) in a murine model and the underlying molecular... 網頁Background: Several phyto-chemicals have been identified and suggested as potential therapeutic options for hepatotoxicity management. Objective: To assess the …

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網頁2024年5月30日 · The model group mice were intraperitoneally injected with DEN 2 mg·kg⁻¹ at 14 d after birth and intraperitoneally injected with 20% carbon tetrachloride (CCl4) … 網頁2024年12月24日 · Carbon tetrachloride (reagent grade, 99.9%), silymarin (≥95%), and CGA were acquired from the Sigma Chemical Co. (St. Louis, MO, USA). All the other analytical grade chemicals and reagents used in this study were received from local chemical companies. 2.2. Animals

網頁2015年4月5日 · Abstract In addition to carbon tetrachloride (CCl4), thioacetamide (TAA) represents a second widely used model for the induction of experimental liver fibrosis, … 網頁2024年4月3日 · Background: The effects of hypoxia inducible factor-2α (HIF-2α) deficiency on liver fibrosis have not been demonstrated in a fibrosis model induced by carbon tetrachloride (CCl 4). We aimed to examine whether hepatocyte-specific HIF-2α deletion could ameliorate CCl 4 -induced liver fibrosis in mice.

網頁2024年5月1日 · To establish hepatocarcinogenesis mouse model, a single dose of 25 mg/kg DEN (N-Nitrosodiethylamine, BioChem Partner, China) was i.p injected into both female and male WT and HKO mice ( N = 8 each group) at 14 days of age, followed by administration of 10% CCl 4 (v/v in corn oil, 8 ml/kg of body weight, Solarbio, China) … 網頁2024年4月9日 · Phenobarbital was administered once as a CYP inducer in the carbon tetrachloride-induced hepatitis model mice. The mRNA expression levels of Cyp3a11 and Cyp2b10 in the liver and small intestine were measured using reverse transcription polymerase chain reaction.

網頁ABSTRACT We investigated the effects of carbon tetrachloride (CCl 4) exposure on liver detoxification.We confirmed that 0.2%-0.8% CCl 4 decreased the liver carboxylesterase …

網頁2024年5月1日 · Carbon tetrachloride CCl 4 is not a drug, but high doses (≥1 mL/kg) do cause reproducible acute liver injury that resembles intrinsic DILI. After APAP, CCl 4 is probably the most common model of xenobiotic-induced acute liver injury. gaming chair keeps leaning back網頁2024年11月26日 · This is the first study to investigate the hepatoprotective effect of CQ on acute liver injury caused by carbon tetrachloride (CCl4) in a murine model and the … black hills christmas train網頁2024年4月3日 · Background The effects of hypoxia inducible factor-2α (HIF-2α) deficiency on liver fibrosis have not been demonstrated in a fibrosis model induced by carbon tetrachloride (CCl 4).We aimed to examine whether hepatocyte-specific HIF-2α deletion could ameliorate CCl 4-induced liver fibrosis in mice. black hills chuckwagon dinner網頁2024年11月26日 · Carbon tetrachloride (CCl 4)-induced acute liver injury in murine models is widely used to investigate potential therapeutic strategies due to its similarities with … black hills christian academy spearfish sd網頁2015年4月1日 · Comparing distress of mouse models for liver damage. This study used receiver operating characteristic curve analysis to quantify the performance of burrowing … black hills christmas tree cutting網頁2015年4月2日 · Here we present our experience with the TAA model, which includes chronic oral exposure in C57BL/6 mice at a fixed dose (300 mg/L in drinking water) for … blackhills church camp網頁2024年4月3日 · Background: The effects of hypoxia inducible factor-2α (HIF-2α) deficiency on liver fibrosis have not been demonstrated in a fibrosis model induced by carbon … black hills church