Web3 Jan 2024 · RGC overexpression of THBS1 enhanced regeneration in both ipRGCs and non-ipRGCs. The trimerization and C-terminal domains promoted regeneration, while the THBS … Web15 Jan 2024 · Thrombospondin 1 (TSP-1, THBS1) is an important extracellular matrix protein secreted by astrocytes. THBS1 increases rapidly in the injured spinal cord segment in rats. Decreasing the expression of THBS1 can effectively prevent pathological changes after SCI [ 10 ]. But the mechanism of THBS1 in SCI still needs to be further explored.

Suppression of Endothelial AGO1 Promotes Adipose Tissue ... - Circulation

Protein extracts from tTA cont. and Thbs1 DTG hearts were generated by homogenizing in immunoprecipitation (IP) lysis buffer (50 mM Tris-HCl pH 7.4, 150 mM NaCl, 1% Triton X-100) supplemented with HaltTM Protease and Phosphatase single-use inhibitor cocktail (ThermoFisher Scientific, #78442), … See more All experimental procedures with animals were approved by the Institutional Animal Care and Use Committee (IACUC) of Cincinnati Children’s Medical Center, protocols IACUC 2016-0069 and 2024-0047. The number of … See more Full-length mouse Atf4 cDNA was obtained from Addgene (plasmid #21845, deposited by Dr. David Ron), amplified by PCR using CloneAMP HiFi PCR premix (Takara Bio, #639298) and cloned into the Cla1 and XhoI sites of … See more Adenoviruses harboring Thbs1, Thbs3, tandem mRFP-GFP-LC3 (Ad-tf-LC3; gift from Dr. J. Sadoshima of the University of Medicine and … See more Hearts were excised, immediately frozen in liquid nitrogen and stored at −80 °C until further use. Cultured primary NRVMs were washed three times with ice-cold 1x PBS, collected, centrifuged … See more http://genome-asia.ucsc.edu/cgi-bin/hgGene?hgsid=792034062_4fOYpBGWEgVLtTYgtYA7aAzFLVOd&hgg_section_primers_close=1 toyota avalon dealer near me

Thrombospondin-1 Mediates Axon Regeneration in …

WebThe THBS1 gene encodes thromboplastin 1, which is involved in angiogenesis and tumor progression, and its increased expression significantly correlates with tumor … Web15 Dec 2011 · Thrombospondin-1 (TSP-1) is an endogenous inhibitor of angiogenesis encoded by the THBS1 gene, whose promoter is activated by p53. In advanced colorectal … Web12 May 2024 · In EC-AGO1-KO mice, overexpression of TSP1 substantially attenuated the beneficial phenotype. In human endothelium isolated from donors with obesity or type 2 … toyota avalon factory rims