Smarca2 phosphorylation
WebJan 24, 2024 · Reversible protein phosphorylation plays a critical role in the regulation of various cellular processes, including intracellular signaling and protein–protein interaction. ... SMARCA2 has been shown to be an essential gene in SMARCA4-related cancer cell lines. Thus, SMARCA2 may be targeted in SMARCA4-related or -deficient cancers. However ... WebAug 28, 2024 · BRM (also known as SMARCA2) interacts with transcription factors and other cellular proteins to modulate transcription activity of multiple genes [2]. It is not …
Smarca2 phosphorylation
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WebJul 1, 2024 · SMARCA2/BRM and SMARCA4/BRG1 are the mutually exclusive DNA-dependent ATPases within the SWI/SNF complexes, which function in mobilizing nucleosomes to regulate transcription, DNA replication and repair, and higher-order chromosome dynamics. SMARCA4 is mutated in a number of cancers, which generally … WebJan 1, 2024 · In preclinical models, BRG1 inactivation increases tumor aggressiveness but enhances sensitivity to drugs that target oxidative phosphorylation and inhibit SMARCA2, EZH2, CDK4, or CDK6. To facilitate translation of preclinical findings into clinical studies exploiting these therapeutic vulnerabilities, we assessed the clinical features of ...
WebAug 28, 2024 · BRM/SMARCA2 promotes the proliferation and chemoresistance of pancreatic cancer cells by targeting JAK2/STAT3 signaling. We reveal a novel mechanism … WebApr 12, 2024 · It plays an oncogenic role in development by regulating the CDK2 (cell cycle checkpoint kinase) and its downstream proteins phosphorylation [70, 71]. Atm is directly involved in p53 phosphorylation. P53 acts as cancer suppressor gene. The P53 protein is involved in the regulation of cell division, proliferation, and DNA damage repair.
WebNov 3, 2024 · The ability of SMARCA2 to compensate for the loss of SMARCA4 has made SMARCA2 an attractive therapeutic target for SMARCA4-mutant tumor types, motivating multiple groups to generate SMARCA2...
WebResearch in the Wang laboratory centers around interface of genetics, chemistry, biology, medicine and biotechnology investigations that explore the protein post-translational modifications (PTMs) and their networks. We are studying bacterial and eukaryotic systems in a multidisciplinary approach that includes expanding genetics codes, protein chemistry, …
WebJul 1, 2024 · Abstract. Background: SMARCA2 (BRM) and SMARCA4 (BRG1) are two mutually exclusive DNA-dependent ATPases of the SWI/SNF complex, which function in mobilizing nucleosomes to regulate transcription, DNA replication/repair and chromosome dynamics. SMARCA4 is known to be mutated in number of cancers lacking targetable … high school hockey tournament 2023 liveWebNov 13, 2024 · Mutations in SMARCA2, a BRM-encoding gene as well as overexpression or epigenetic silencing were found in various human diseases including cancer. Missense … how many children did ricky nelson fatherWebNov 2, 2024 · SMARCA2 could be a synthetic lethal vulnerability in SMARCA4-mutant cancers. Prior reports have shown that SMARCA2 retains expression in SMARCA4-mutant … how many children did ringo starr haveWebDec 10, 2024 · SMARCA2 Summary The field of targeted protein degradation promoted by small molecules has been intensively studied. Bifunctional compounds function to recruit … high school hockey tournament 2023 resultsWebMar 21, 2024 · SMARCA2 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A, Member 2) is a Protein Coding gene. Diseases associated with SMARCA2 include Nicolaides-Baraitser Syndrome and Blepharophimosis-Impaired Intellectual Development Syndrome.Among its related pathways are Gene expression … how many children did robert burns haveWebDec 7, 2024 · SMARCA2, an evolutionarily conserved catalytic ATPase subunit of SWI/SNF complexes, has been implicated in development and diseases; however, its role in mammalian ovarian function and female fertility is unknown. Here, we identified and characterized the 3′-UTR of the porcine SMARCA2 gene and identified a novel adenylate … how many children did robert baratheon haveWebJ. Jesús Naveja, ... José L. Medina-Franco, in Advances in Protein Chemistry and Structural Biology, 2024 3.6 Epigenetic Targets With Scaffold Hops. In clear contrast to the … high school hockey tickets