Incidence of rhabdomyolysis with daptomycin

Author: amtk

August undefined, 2024

WebDec 13, 2024 · The incidence of rhabdomyolysis was significantly higher following concomitant daptomycin and statin use than with daptomycin alone (OR = 11.60, 95% CI … WebRhabdomyolysis is a known possible complication associated with daptomycin therapy. However, previous findings were predominantly in phase 1 and 2 trials, and the effects were thought to be minimized by once-daily dosing. Prior elevations in serum CPK levels and/or myopathy have generally occurred at least 7 days after the initiation of therapy.

Full article: Acute-onset rhabdomyolysis secondary to sitagliptin …

WebNov 17, 2024 · However, the risk of developing rhabdomyolysis from statin therapy is very low, around 1.5 for each 100,000 people taking statins. Rhabdomyolysis or milder forms … WebDec 4, 2024 · National Center for Biotechnology Information slow pumping heart

Safety outcomes with high‐dose daptomycin in patients with …

WebDaptomycin is reported to cause an elevation in creatine kinase levels, although frank rhabdomyolysis is rare. An even more infrequent occurrence is the simultaneous development of acute kidney injury and drug-induced liver injury with rhabdomyolysis. Daptomycin and rifampin combination are used for synergistic bactericidal action against … WebDaptomycin requires prior approval. Baseline CK followed by weekly CK should be measured in patients placed on daptomycin due to increased risk of rhabdomyolysis. Increased dose of daptomycin may be indicated with documented MRSA bacteremia. Infections due to fungi, mycobacteria, or Actinomyces require longer durations of therapy – WebEarly-onset rhabdomyolysis related to daptomycin use. Early-onset rhabdomyolysis related to daptomycin use Int J Antimicrob Agents. 2007 Nov;30(5):472-4. doi: … software update monitor pro

A case report and literature review of daptomycin-induced liver …

Daptomycin: An overview - UpToDate

WebNov 23, 2024 · Citation 8 In contrast, a study by Graham et al Citation 9 in 2004 reported an average incidence of 0.44 in 10,000 patients (who developed rhabdomyolysis) being treated with atorvastatin, simvastatin, or pravastatin, with a 95% confidence interval of 0.20–0.84. These patients had been taking lipid-lowering agents alone or in combination. WebTo determine the incidence and characteristics of significant adverse effects in patients receiving high-dose daptomycin with severe renal dysfunction. ... One patient experienced significant CK elevation while on daptomycin therapy with rhabdomyolysis; however, daptomycin was continued as there was an alternative explanation for an elevated CK ... slow pulse rate in adultsWebNov 10, 2024 · A typical adverse reaction of daptomycin is creatine phosphokinase (CPK) elevation, which occurred in 6.7% of patients in a phase 3 study [ 2 ]. This adverse reaction is dose-dependent, and Lai et al reported a significantly higher incidence of CPK elevation at doses of ≥8mg/kg than at <8mg/kg [ 3 ]. software update monitors

"WebMar 7, 2024 · INTRODUCTION. Daptomycin is a lipopeptide antimicrobial with activity against gram-positive organisms, including antimicrobial-resistant pathogens such as … " - Incidence of rhabdomyolysis with daptomycin

Incidence of rhabdomyolysis with daptomycin

Safety outcomes with high‐dose daptomycin in patients with …

WebDaptomycin is associated with a number of adverse effects including eosinophilic pneumonia, hypersensitivity reaction, myopathy, rhabdomyolysis, headache and … WebJan 16, 2024 · Rhabdomyolysis means dissolution of skeletal muscle, and it is characterized by leakage of muscle cell contents, myoglobin, sarcoplasmic proteins (creatine kinase, lactate dehydrogenase, aldolase, …

Did you know?

WebDaptomycin has been associated with raised creatine kinase activity, with a reported incidence of 2.8% in phase III clinical trials (167 A). Rhabdomyolysis has also been described (168 A ) . A 45-year-old woman with refractory acute myeloid leukemia was given intravenous daptomycin 550 mg (6 mg/kg) every 24 hours because of bacteremia due to ... WebFactors conferring increased risk for daptomycin-associated myopathy or rhabdomyolysis include : … Overview of the causes and treatment of hyperphosphatemia … lysis syndrome, muscle necrosis ( rhabdomyolysis ), and, rarely, marked hemolysis or …

Webin patients placed on Daptomycin due to increased risk of rhabdomyolysis. Infections due to fungi, mycobacteria, or Actinomyces require longer durations of therapy – consult … WebMar 21, 2024 · Incidence not known Diarrhea, watery, and severe, which may also be bloody dry cough puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue stomach cramps or tenderness Other side effects of Daptomycin Some side effects of daptomycin may occur that usually do not need medical attention.

WebDaptomycin, a cyclic lipopeptide antibiotic, has bactericidal activity against Gram-positive organisms ... Although daptomycin causes unique adverse drug reactions such as elevation of creatine phosphokinase or rhabdomyolysis, the detailed ... and incidence of CPK elevation. Second, an in vitro pharmacological study was conducted using cul- WebConclusion: Daptomycin can be associated with elevations in CPK level and rhabdomyolysis despite reduction of dose. A baseline CPK level before starting …

http://cid.oxfordjournals.org/content/42/12/e108.full#:~:text=To%20our%20knowledge%2C%20this%20is%20the%20first%20documented,0.2%25%20of%20the%20study%20population%20reported%20myopathy%20%5B2%5D.

WebRhabdomyolysis has been reported in up to 5 percent of treated patients receiving daptomycin . Factors conferring increased risk for daptomycin-associated myopathy or rhabdomyolysis include : … Overview of the causes and treatment of hyperphosphatemia … software update on cingular flip ivWebof daptomycin use. Rhabdomyolysis is more commonly seen in a dose-dependent manner, especially at higher doses of daptomycin (8 mg/kg/day) compared to standard doses (6 mg/kg/day) [3]. Here, we described a case of recurrent hyperkalemia when daptomycin was initiated and completely resolved once daptomycin was discontinued. software update notification won\u0027t go awayWebOct 15, 2024 · Background: Daptomycin-associated myopathy has been identified in 2%-14% of patients, and rhabdomyolysis is a known adverse effect. Although risk factors for … software update note 9WebMar 1, 2024 · irregular heartbeat. irritability. itching in the genital or other skin areas. itching, pain, redness, swelling, tenderness, or warmth on the skin. lightheadedness. loss of appetite. loss of consciousness. lower back or side pain. mood changes. software update nintendo switchWebOct 5, 2024 · The primary outcome was overall incidence of creatine phosphokinase (CK) elevation, myopathy and rhabdomyolysis. Results and discussion A total of 74 patients who received daptomycin therapy were screened with 50 included in the study. slow puncture repair kitWebJan 1, 2024 · There was no other potential source of rhabdomyolysis in this patient and this is the first case report documenting concomitant renal injury as well as DILI secondary to daptomycin administration. Another case reported in 2007 similarly found elevations in CK as well as transaminase levels with significant muscle weakness after daptomycin ... software update note 5WebThe incidence of myopathy and rhabdomyolysis were highest during the first year and then decreased during the subsequent years of treatment. ... Daptomycin Clinical Impact: Cases of rhabdomyolysis have been reported with simvastatin administered with daptomycin. Both simvastatin and daptomycin can cause myopathy and rhabdomyolysis when given ... software update on android