Web2 days ago · Hyperhemolysis syndrome (HHS) is an uncommon transfusion reaction described in several hematologic disorders, including sickle cell disease (SCD). HHS is characterized by a decline in hemoglobin (Hb) values below pre-transfusion levels following transfusion of red blood cells (RBCs), coupled with laboratory markers consistent with … WebPacked red blood cells (PRBCs), stored for prolonged intervals, might contribute to adverse clinical outcomes in critically ill patients. In this study, short-term outcome after transfusion of PRBCs of two storage duration periods was analyzed in patients with Acute Respiratory Distress Syndrome (ARDS). Patients who received transfusions of PRBCs were …
Alloimmunisation against red blood cells in sickle cell disease ...
WebIn DHTR both transfused and autologous RBCs hyperhemolysis occurs and may be accompanied by reticulocytopenia, leading to worsening of the anemia. 2 SCD patients develop RBCs alloantibodies much more frequently than non-SCD transfused patients, in addition to having a significantly higher risk of suffering from DHTR. 3 The incidence of ... WebJun 1, 2003 · Objective. Alloimmunization in patients with sickle cell disease (SCD) has a reported incidence of 5% to 36%. One complication of alloimmunization is delayed hemolytic transfusion reaction/hyperhemolysis (DHTR/H) syndrome, which has a reported incidence of 11%. In patients with SCD, clinical findings in DHTR/H syndrome … robins air force base honor guard
Targeting Macrophage Activation in Hyperhemolysis Syndrome …
WebFeb 1, 2024 · Hyperhemolysis syndrome (HHS), is a rare hemolytic transfusion reaction characterized by a lower hemoglobin (Hb) than pre-transfusion, fever and pain, decreased reticulocyte count, hyperbilirubinemia, raised lactate dehydrogenase, and hemoglobinuria generally occurring within two weeks of last transfusion. 3, 4 The cause of the precipitous … WebNov 1, 2024 · Hyperhemolysis syndrome is a potentially fatal transfusion complication, especially in patients with SCD. Multiple mechanisms, including “bystander hemolysis,” … WebSuch hyperhemolysis can be particularly fatal in patients with SCD for reasons that remain incompletely understood. Figure 1. Delayed-type hemolytic transfusion reactions. (A) Exposure to a red blood cell (RBC) alloantigen through transfusion or pregnancy can result in the development of alloantibodies (allo) that quickly evanescence over time ... robins air force base recreation center