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Web4 hours ago · The symptoms emerge in childhood and include progressive muscle weakness and atrophy in the feet and legs. Tay-Sachs disease is caused by mutations in the HEXA gene, [18] leading to muscle weakness, impaired coordination, speech problems, and psychological disorders. Tay-Sachs occurs in 1 in 100,000 live births. WebMar 29, 2012 · Unfortunately, people who have chronic fatigue syndrome may become depressed. And while depression doesn’t cause chronic fatigue syndrome, it can … WebJul 26, 2024 · Kidney diseases. Problems with kidney function can cause metabolic waste products, such as creatinine, to build up in the muscles. This can result in muscle … incawasi